Over the last few months, there were several of us who have failed miserably on high dose T3 or NDT, made quite remarkable improvement after working ourselves up slowly to full replacement doses of T4 (which also required some initial adjustment period). At least one person I know of even had elevated rT3 and still did better on T4 than on T3 which goes completely against the grain of current alternative thyroid theories. We have already talked plenty about how TSH is essentially useless...
T1AM decreases thyroid production without effect on HPT
T1AM decreases thyroid production without effect on HPT